Engineered bacterially expressed polypeptides: Assembly into polymer particles with tailored degradation profiles

DHC Chang; APR Johnston; KL Wark; K Breheney; F Caruso

Journal article

Engineered bacterially expressed polypeptides: Assembly into polymer particles with tailored degradation profiles

DHC Chang, APR Johnston, KL Wark, K Breheney, F Caruso

Angewandte Chemie International Edition | WILEY-V C H VERLAG GMBH | Published : 2012

DOI: 10.1002/anie.201106033

Abstract

In nature, the sequence of amino acids in a protein is determined by the genetic code. Biosynthesis of polypeptides by bacteria can be used to exploit this natural process to afford exact control over properties such as molecular weight, chemical functionality, and structure. It is demonstrated how control over the positioning of functional groups can be used to tune the degradation of assembled polypeptide particles (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

University of Melbourne Researchers

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was supported by the Australian Research Council under the Federation Fellowship (FF0776078) and Discovery Project (DP0877360) schemes. We thank Dr. Henk Dam for his assistance with mass spectrometry, Dr. Christopher J. Ochs and Dr. Zhiyuan Zhu for their assistance with NMR analysis, and Dr. Lillian Lee for her assistance with CD spectroscopy.